Locking this topic since the same question was posted in https://forum.mysensors.org/topic/9658/domoticz-arduino-usb/ Feel free to continue the discussion there.
@d-dow welcome to the MySensors community!
see https://forum.mysensors.org/post/64477 and https://forum.mysensors.org/post/57240 and https://forum.mysensors.org/post/59833
