@Maurizio-Collu I've had it running by using the pin layout as described in the wiki site in my previous post. Of course I had to change the CS(N) pin in MyConfig.h (CS-pin to 53). Don't forget to put it back to original if you're using it on other arduino types !! As far as I can remember (it was more that a year ago when I tried this) that was the only change needed to get it working. See table below; use Mega2560 with RF24 library. Hope this helps. Boozz