This problem has been resolved. It appears my ANKER 10 port USB Hub is the problem. It's associated with the lower 4 ports of the hub. The remaining 6 are OK. I'm not sure what the actual problem is yet. The hub has a 60W power supply attached so I doubt it's a power issue...maybe noise? I now have a 10 port Amazon Hub which works well. As for the DTR signal, I've always used it and have seldom used the reset buttons. Also, I think most of the Arduinos and clones have it implemented through the serial convertor chip as well. It's also on all the ESP32 and ESP 8266 clones I've used. Again, thanks everyone for your comments and suggestions.
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RE: Pro Mini issues