I can not select the serial port yet, so could not test it further, likely have to do some mapping in wine.
Took some time to find out but after:
Adding a mapping from the Linux serial port to the Wine dosdevice configuration:
ln -s /dev/serial/by-id/usb-FTDI_FT232R_USB_UART_* ~/.wine/dosdevices/COM3
Adding to ~/.wine/system.reg:
[Hardware\\Devicemap\\Serialcomm] 1231984861 @="" "Serial0"="COM1" "Serial1"="COM2" "Serial2"="COM3"
I could start MYSController.exe and select COM3 and get:
But after pressing OK things look to work however:
@tekka : Thanks!